The proposal that the activity of some place cells may contain information about reward-predictive value is compatible with recent evidence suggesting that behavioral sequences are replayed in hippocampal place cells in reverse order during awake states (Foster and Wilson, 2006).
Where the control treatment was not placebo or no treatment, this latter approach is problematic if the treatments had a clinical effect, as the predictive factors may contain treatment effect modifiers common to both treatments.
The automation is applied to a special design problem of Model-based Predictive Controls that may contain the heuristic modeling uncertainty in case of custom modeling, and that also requires very frequent system analyses during development.
Third, the predictive putative targets may contain many false positives.
Rather, the results suggest that the activity of certain hippocampal neurons may contain sufficient information about the reward-predictive value of different sets of task-relevant signals.
Intuitively, including the lower confidence paths can hurt predictive performance because these source target connections may contain false-positive PPI and not actually affect connectivity when they are broken.
This weaker correlation was expected as full-models may contain irrelevant and highly correlated variables which directly influence the models predictive power by causing them to over fit the training sets.
As a result of the redundancy within the 'seed' region, predictive algorithms have suggested that up to a third of all genes may contain putative single or multiple MREs and might therefore be regulated by changes in miRNA expression [ 22].
Thus, the results shown in Table 4 may contain a portion of overestimation of model fit in the discovery dataset analysis results, indicating that bias could be embedded in predictive modeling when using the association tests approach in marker selection.
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