Here, certain glycoproteins were specifically detected in exosomes and may constitute markers.
In summary, we found that tumor expression of cIAP1/2, cIAP2, Survivin, procaspase-8, cleaved caspase-8, procaspase-3 and caspase-7 expression correlates with clinicopathological features of prostate cancer, indicating that these proteins may constitute markers of local disease.
Since the phosphoproteome changes during cancer development and phosphoproteins may constitute useful markers for the early individuation of NB differentiation process, the effects of ATRA on serine- and tyrosine- phosphorylation patterns in NB cells were investigated.
On the other hand, exosomes are enriched in specific glycoproteins that may constitute exosome markers.
These proteins may constitute valuable markers for diagnosis, prognosis or therapy, but this has to be confirmed in future studies.
Several neutrophil-granular proteins released by activated neutrophils may constitute fecal markers of intestinal inflammation, including lactoferrin (LF), calprotectin (Cal), polymorphonuclear neutrophil-elastase (PMN-e), and lysozyme (Lys) [ 4], with Cal and LF appearing to be the most promising surrogate biomarkers.
In conclusion, as was recently shown in pancreatic cancer, anti-p53 serum antibodies may constitute a marker of relative 'good prognosis' in a subgroup of patients exhibiting one or several markers traditionally thought to be of bad prognosis.
Conclusion: Our results support a role of survivin in colorectal carcinogenesis while the −31G/C snp may constitute a marker of survival.
Medication count may constitute a marker for severity of illness or an expression of conventional medicines not working, however this proposition could not be tested.
Atypical low morning cortisol in early pregnancy may be an indicator of HPA dysfunction, however, additional research that includes adverse pregnancy outcomes is needed to determine if these atypical cortisol levels may constitute a marker for risk later in pregnancy.
On clinical grounds, bvFTD and SD were predicted to have the most marked derangements of emotional salience processing, yet patients with AD here showed abnormal affective coding of sounds: this may constitute a marker of heightened behavioral sensitivity to emotional stimuli underpinned by relative enhancement of salience network activity, recently proposed as a hallmark of AD [8], [14].
