Thus, mild hypothermia may also up-regulate NMDARs and consequently activate the downstream pro-survival CREB signaling pathway.
Once they are critically short, telomeres become dysfunctional and consequently activate a proliferative arrest called replicative senescence.
It is assumed that bleeding leads to hemodynamic compromise, decreasing tissue oxygenation (for example, because of anemia or hypotension) and consequently activating adaptive mechanisms, which may trigger a chain of other adverse complications [ 62].
Therefore, while on the one side the HDAC inhibitor panobinostat functions at the histone level, acetylating and consequently activating the GADD45G promoter, on the other side the SIRT1 activator may function at the transcription factor level, deacetylating and consequently inhibiting the function of the GADD45G repressor.
They suggest that C/EBP α may act as a positive regulator binding to FTO promoter and, consequently, activates the gene transcription.
Collectively, our data suggest that C/EBP α may act as a positive regulator binding to FTO promoter and consequently, activates the gene transcription.
Therefore, we hypothesized that inflammatory effects of high glucose may be, at least in part, mediated through low Gas6 levels as well as reduced TAM signaling and, consequently, activated innate immunity.
STATa induces expression of the CudA transcription factor [16] that consequently activates expression of tip-organiser genes such as expl7 [18].
Apoptosis may be linked to lysosomes and lipofuscin in that oxidant-induced lysosomal rupture can cause leakage of lysosomal cathepsin D and mitochondrial cytochrome c, consequently activating caspases, which trigger apoptosis [ 8, 9].
M2 polarization is determined when circulating immune cells reach to the inflammatory lesion and are consequently activated there.
