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Such modular structures may confer selective advantage by allowing the optimization of gene expression within each module and therefore minimizing the impact of genetic variants outside the module.
Amino acid substitutions in the envelope region of the viruses may confer selective pressure towards CKR-L3-use.
Amino acid substitutions in the envelope region of these viruses may confer selective pressure towards CKR-L3-use.
We believe that some morphological traits of the copulatory organ and of the sperm may confer selective advantages in sperm offense and/or sperm defence (e.g. [ 48]).
Losses of gene in a given species can be considered an adaptive event that may confer selective advantages to an organism [ 54].
Here, we review the possibility that in neoplastic transformation aberrantly regulated transcription factors mediate de-/and trans-differentiation steps that may confer selective advantages to the evolving cancer cell.
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We therefore considered it possible that none of these mutations is important for the formation of this lineage (that is, they may not confer selective advantage compared with the non-mutants).
While the CNIs that occur at similar frequencies in LG-SIL and HG-SIL are consistent with early events, those that are significantly more frequent in HG-SIL may confer a selective advantage to LG-SIL cells and contribute to progression via clonal selection.
This phenomenon, termed CO interference, occurs pervasively in eukaryotes and may confer a selective advantage.
The need for optimizing MGMT protein design is supported by recent observations suggesting that the P140K mutant of MGMT, developed to be resistant to inhibitors such as O6-benzylguanine, may confer a selective disadvantage when expressed at high levels.
These results suggest that polyphosphate synthesis and degradation may confer a selective advantage to oligotrophs in Pi-limited environments.
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