(Evolutionary biologists speculate that the gene has survived for so long because, like the sickle-cell mutation, it may confer resistance to malaria).
Molecular alterations in downstream effectors of epidermal growth factor receptor may confer resistance to epidermal growth factor receptor inhibitors.
In all, these analytical models identify bacterial pathways that may confer resistance to colitis and serve as biomarkers for patients at high risk of developing CTLA-4 blockade-induced colitis.
A shorter spacer length results in higher population density (which may confer resistance to invasion in real populations), while longer spacer length allows the population to spread more quickly.
Genetic engineering provides a complementary tool to Musa breeders who can introduce today transgenes that may confer resistance to bacteria, fungi and nematodes, or enhance pro-vitamin A fruit content.
Background: Mutations in the thymidine kinase (TK) and DNA polymerase (pol) genes of herpes simplex virus (HSV) may confer resistance to antiviral drugs, particularly in the context of immunosuppression induced by infection with the human immunodeficiency virus (HIV).
Anti-apoptosis gene upregulation may confer resistance to apoptosis in PNH and related disorders, and provide a common compensatory mechanism after bone marrow injury that allows survival and growth of remaining hematopoietic stem cells.
Most of the loci associated with blast resistance against M. oryzae in rice have been identified in controlled environments and with single isolates, and such loci may confer resistance to only a small faction of the M. oryzae strains.
Although 21 BPH resistance genes have been identified, further efforts are needed to identify new resistance genes from diverse genetic sources which may confer resistance to new biotypes of BPH.
These results again suggest that high level of ER-α36 expression may confer resistance to tamoxifen.
MYC expression may confer resistance to rapamycin by disrupting the balance between proliferation and apoptosis or senescence.
