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These differences suggest that removing liver cells from their in vivo environment may confer properties of plasticity not representative of in vivo biology.
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Such properties may confer cytotoxic properties to obatoclax in addition to Mcl-1 inhibition and might explain why this molecule can kill Bax/Bak-null cells in certain contexts [ 33].
Other variations may confer therapeutic properties besides antibiotic functions.
Similar to complement component C3, FcA2M-2 has a catalytic histidine, which may confer opsonic properties on this shrimp A2M.
The result is a concatenation of assorted bits of the "parental" genes that may confer unexpected properties on the protein that results from the activities of the new gene.According to Russell Howard, Maxygen's boss, the company's researchers have so far managed to shuffle the DNA for an enzyme called subtilisin from 26 different strains of bacteria.
It is hypothesized that this region may confer differential properties of DOCK family function.
We explored whether eHsp90 may confer invasive properties to GBM via regulation of EphA2 mediated signaling.
The viruses are all oncogenic, and may confer oncogenic properties to DDX3.
Nanomaterials have increased surface to volume ratio compared with their bulk materials, and this may confer interesting properties, such as increased mechanical strength.
The high levels of lipid hydroperoxides present in LDL oxidized by iron at lysosomal pH may confer atherogenic properties to the LDL, which differ from those of copper-oxidized LDL.
Neo- and subfunctionalization can be brought about on different levels: Mutations in protein coding sequences may confer novel properties e.g. for transcription factors altered DNA binding sites and thus modified target gene lists.
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