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It may confer its growth effects by trans-activating target genes required for cell proliferation in nucleus [ 56].
The conformational change in ALG-2 may confer its ability to discriminate between Sec31 subunit isoforms.
Thus, sodium arsenite may confer its cytotoxic effect partly through the aberrant activation of CDKs and the resultant perturbation of cell cycle progression.
Bendamustine, a drug developed in the former East Germany, is an alkylating agent that appears to overcome cross-resistance to other alkylators and contains a benzimidazole ring, which may confer its unique properties [ 9].
Taken together, these results suggest that Alk5 signaling may be constitutively active in β cells, that sustaining mature β cell phenotype depends on constant inhibition of this signal, and that the inhibition of Alk5 signaling may confer its effect by inducing expression of β cell transcription factors including MafA, Nkx6.1, and Pdx1.
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GLP-1 may therefore confer its cardioprotective effects by inducing a shift towards greater myocardial glucose utilization, an adaptive response which is known to be more oxygen efficient than fatty acid metabolism [ 43], but which is impaired in the context of insulin resistance.
Goldstein views campus life with a sharp eye, documenting the jealousies within academic departments, the solitariness of a devoted physics scholar, "too alone to have any idea of how lonely he is," and the hovering cloud of threat or promise that Stockholm may call to confer its Nobel blessing on a member of the faculty.
In the formation of a government, the people may confer upon it such powers as they choose.
There is considerable evidence, and even more speculation, that a non-alcoholic component of red wine, resveratrol, may confer health benefits of its own.
The critical role of FXR in modulating intestinal tumorigenesis is probably due to its regulation of BA metabolism and detoxification, and its activation may confer protection from BA-induced tumor promoting activities.
32 Thus, it is plausible that its use may confer similar clinical benefits, but these have yet to be elucidated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com