Sentence examples for may confer instability from inspiring English sources

The relatively low level of expression of the "2.5 kb" construct suggests, however, that this fragment may confer instability of the fusion transcript; this may result in less apparent further destabilization by the shRNA expression constructs.

A recent OCT study on 266 lesions suggested that 80 µm might be the critical cap thickness that may confer instability to a coronary plaque in living patients [ 17].

The other 15% mutations may impair substrate binding, which may indirectly still confer instability.

All of these data suggest that the chromatin structure/gene composition of this compartment of the S phase is conserved and may be important for the maintenance of cell stability and if defective may confer genetic instability.

AREs can confer instability to transcripts, which is antagonized by HuR binding to these sites (Fan & Steitz, 1998).

Moreover, mutation points present in 5'- flanking region may confer a higher instability to the mRNA.

Nevertheless, one has to be cautious as some mutations may confer loss of function without necessarily conferring transcript and protein instability.

However, direct observation of the rise and segregation of duplications is much scarcer owing to their rarity, instability and the subtle phenotypic effects they may confer.

Shorter expansions may confer a growth advantage during culture, as has been demonstrated in myotonic dystrophy, where the somatic instability of a CTG repeat expansion in tissues is poorly represented in lymphoblastoid cell lines 19, 20.

Chromosomal instability (CIN) and aneuploidy are molecular features of most sporadic colorectal cancers (~85%) and may confer a worse prognosis [ 1- 3].

A mutation that confers lethality, he explained, may confer another advantage scientists have not pinned down.