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An increase in water content in muscle may precede increases in muscle protein synthesis, which may confer functional (fitness) and physiological (e.g. glucose disposal) benefits with a longer period of follow-up.
Variation in the pathogenic phenotype of B. pseudomallei natural isolates could reflect either the loss or acquisition of accessory genetic material through horizontal gene transfer events, which may confer functional diversity among individual strains.
It appears that different combinations of receptor subunits may confer functional specificity [ 38].
Therapeutic options to improve functional capacity are still very limited, but it is plausible that targeting abnormalities impeding oxygen transportation and/or utilization may confer functional benefits.
Moreover, apart from a few exceptions, studies of cognitive deficits have ignored factors that may confer functional resilience against structural brain damage.
There are 12 GABAB1 variants (a-k including c-a and c-b) in total, the majority of which are secreted forms that may confer functional differences to the GABAB1/B2 heterodimer [325].
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The fact that cancer-specific oncogene transcripts have a higher functional content compared to those normal specific suggests that, in some instances, oncogene-derived cancer-specific transcripts may confer novel functional properties to protein products potentially having a role in cancer cells.
One possibility is that cardiac tissue express several leptin receptors isoforms (Lollmann et al., 1997; Wold et al., 2002) that may confer distinct functional roles.
To detect if the protein sequence divergence of MCPH1 among primates may confer any functional alterations, we selected eight known down-stream genes regulated by E2F1 and MCPH1: p107[19], p18[[ 19], p27[ 27], p14[ 28], p14 ARF [ 19], Caspase7[ 19], CyclinE1[ 19] and hTERT[ 26].
Moreover, the finding of significant independent associations in both dominant and additive inheritance modes for the F-1 SNPs, and recessive and additive inheritance modes for the S-1 SNPs, means that the search for the causative mutation should take into account the possibility that a single copy may confer a functional effect.
Indeed, transduction models suggest that as little as one ion channel per stereocilium, below the detection limit of conventional immuno-fluoresence techniques, may be sufficient to confer functional mechanotransduction.
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