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In contrast with COX-2 deletion or inhibition, PGI2 formation is augmented in mPGES-1−/− mice an effect that may confer cardiovascular benefit but may undermine the analgesic potential of inhibitors of this enzyme.
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This favorable shift in n-3 lipid profile may confer preventive cardiovascular benefits in this young population at high risk for early coronary heart disease.
Our study indicates that systemic inflammation, as reflected in an elevated CRP, persists in a sizable number of RA patients with minimal or no clinically detectable joint disease and thus may confer increased cardiovascular risk upon these patients.
In light of recent research showing that arterial stiffness was a predictor of cardiovascular outcomes, our results may suggest that in the longer term, oral TU could potentially confer cardiovascular benefit through its effects on arterial stiffness.
In IDNT [ 10], irbesartan alone did not confer cardiovascular protection compared with placebo or amlodipine.
Crucially, a lower dose of fish oil supplementation does not confer cardiovascular protection (Roncaglioni et al., 2013).
Thus, a hypothesis that a group of PM chemical constituents and related sources may confer greater PM cardiovascular toxicity is reasonable based on the existing literature.
Darapladib inhibits Lp-PLA2 activity in plasma and in arterial plaques and may confer clinical benefit in preventing cardiovascular events.
35 Thus, therapies with long-term improvements in both glycemic control and cardiovascular risk factors may confer a long-term health advantage in diabetic patients.
11 Evidence suggests that even brief exposure (eg, 30 min) to SHS has adverse cardiovascular health consequences, 12 which may confer a more salient health risk for those who are vulnerable (ie, individuals with existing cardiovascular or respiratory conditions).
Antipsychotics may confer long term benefits and risks, including cardiovascular disease (CVD) risk.
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