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Doses ranging up to 40,000 IU/day of vitamin D3 are probably safe for healthy individuals,, and enzyme polymorphisms affecting vitamin D metabolism may conceivably increase tolerability in patients with autoimmune disorders.
Obesity may conceivably increase vascularity as a result of poorer temperature control-induced persistent vasodilation, but secreted products of fat cells (adipokines) and macrophages in fat are also postulated to induce new blood vessel formation.
It is unclear what effect this has on test accuracy but it is likely to focus attention on a particular area of the breast and may conceivably increase the diagnostic test sensitivity.
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Fourth, the impact of repeated clinical assessments and rating of relatively small changes in clinical severity combined with regular dose increases, may conceivably have increased the placebo response rates resulting from increased optimism, a tendency to over-report improvements and belief that higher doses are more likely to be more effective than lower doses.
Thus, individual growth rates of R. argentea may conceivably have increased (if food availability has increased more rapidly than biomass), decreased (if the converse is true), or remained the same.
4, 21, 47 Ensuring that adults receive both doses of a 2-dose vaccine poses logistical challenges that may require the development of new or expansion of existing programs that could conceivably increase the cost of vaccinating adults.
If implemented, it is hypothesized that the F-CGRT may be useful in guiding development of mentored research programs for URMs and could conceivably increase the effectiveness of such interventions on participants' career outcome behaviors.
For instance, Asians may experience racial discrimination in the workplace and great pressure to succeed in professional environments, which can conceivably increase stress in ways that displace sleep [ 40- 42].
Shared aetiological factors which may conceivably explain the increased risk of a second primary cancer after the diagnosis of MCC include exposure to ultraviolet-radiation, immunosuppression or MCV infection.
Increase in the distribution of these modifications within the gene body may conceivably explain the increased rate of transcription, as H3K4me3 has also been suggested to stimulate transcriptional elongation [ 43].
The enhanced intrinsic vasodilator capacity of active muscle beds following training may conceivably result from the well established increase in capillary density that occurs with training (Andersen and Henriksson 1977).
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