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Recruitment to trials is complex and often protracted; selection bias may compromise generalisability.
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Qualitative research might be carried out to identify a more culturally appropriate wording for this item but changes to an established measure should generally be made cautiously because changes made locally may compromise the generalisability of findings.
The failure may compromise the treatment outcome.
Immature heart function may compromise survival.
These limitations may compromise our findings.
Damage to DNA may compromise genomic integrity.
Continuing the fast may compromise your health.
An additional threat to generalisability was the study's focus on internet-enabled participants; this compromises generalisability to population screening programs that include individuals who are not active internet users.
Though the analysis was adequately powered for statistical comparisons between those who did and did not accept catch-up MMR within the sample, the modest response rate may have compromised the generalisability of the sample to the wider population from which it was drawn.
Finally, the recruitment of study participants (purposive and snowballing) may have compromised the generalisability of the findings.
There may be a bias towards coding more severe cases of AIRD, which would compromise the generalisability of our findings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com