High density mapping of familial cases has revealed a commonly shared haplotype in a locus near 13q14 that may comprise susceptibility genes for the pathogenesis of CLL.
This unusually high number of transcribed genes in Alexandrium is unlikely to represent unique functional categories; rather many may comprise large gene families that arose by extensive gene duplication events.
This class of genes may comprise homozygously deleted genes which are frequently lost in specific cancers due to their physical vicinity to tumor suppressor genes as well as genes which have become essential genes in malignant tumors but not in normal tissue due to loss of redundancy within central cellular biochemical pathways.
Actually, the allele specificity of nested PCRs can prove to be rewarding, as the orthologous modules may comprise different CYP21 genes, as seen in the case of the chimeric CYP21 gene.
Most of these were not well enriched in expression data, and thus they may comprise sets of genes on whose promoters AHR is poised but not currently active or that may be silenced by epigenetic mechanisms, such as hypermethylation.
These genes may comprise a core group of protein-coding genes that are central to REST-meditated gene silencing.> The Xenopus NRSE screen successfully identified 25 of 32 bona fide REST target genes [ 26].
Seven genes (H5, H9, H10, H11, H16, H17, and Hdic) were mapped on chromosome 1A, and these genes may comprise a cluster (or family) of Hessian fly resistance genes in the distal gene-rich region of wheat chromosome 1AS [ 19, 20, 30, 31].
The observation that SPOP and the adjacent NXPH3 genes are both amplified in ER+ cell lines and overexpressed in ER+ tumors is consistent with the hypotheses that these two genes may comprise an amplicon that is commonly amplified in ER+ tumors.
Moreover, proteome profiles of cells grown under phosphate-rich or phosphate-limited conditions revealed that the overall phosphate response of E. coli may comprise up to 400 genes [ 11].
