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While recognition of this underlying complexity may complicate studies, it is a necessary complication, which may hold the key to explaining how a single locus can give rise to at least four human diseases, all with distinct clinical and pathological features.
Moreover, the disturbance caused to bacterial communities during handling of frogs may complicate studies that investigate changes in bacterial communities over time.
A specific phenomenon that may complicate studies in this genus relates to the remarkable degree to which Plasmodium proteins are enriched in non-globular domains [ 10].
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Importantly, different DNA extraction methods may complicate microbiome studies.
Two issues may complicate genetic studies.
Furthermore, postprocessing and modeling methods may affect the results and may complicate comparison across studies [39].
However, these techniques can be overly sensitive to the data and may complicate comparisons across studies.
Although our probes excluded SNPs, the detected CNV regions overlapped with a large number of HapMap SNPs (13, 14) (121 994 and 150 516 SNPs for CEU and YRI, respectively), and almost all of the regions (96% for CEU and YRI) overlapped with at least one SNP, which may complicate disease-association studies, as described in Discussion.
Although in our study a control group with a comparable distribution of hematological malignancies was used, this intriguing loop may complicate the interpretation of studies in this field.
Although a large number of traits may complicate interpretations from genecology studies, multivariate statistics such as principle component analysis may be used to reduce the number of interacting factors and make it easier to consider several uncorrelated factors when delineating seed zones (Campbell 1986; St. Clair et al. 2005).
Some limitations and features of the RUSH study may complicate a direct comparison with most HIIT protocols cited above: (1) due to the study protocol the exercise groups were not evaluated in parallel but consecutively.
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