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Exact(6)

As an alternative to animal studies, this model may closely reflect early stages of cartilage regeneration, allowing the evaluation of promising biomaterials with/without chondrogenic factors.

As it may closely reflect underlying pathogenic processes in the salivary gland, analysis of saliva from pSS patients is viewed as a promising method of diagnosing pSS.

These results demonstrate a link between oxidative stress and clinical parameters of disease activity and suggest that microscopically assessed levels of 4-HNE may closely reflect clinical scores of IA.

If this is true, changes in retinal pathology may closely reflect changes in microvascular pathology in these other vascular beds, and people with the most rapid progression in retinal pathology may be the ones most likely to suffer incident CV outcomes.

This new in vitro model may closely reflect the complex process of early stage in vivo destruction in RA and help to elucidate the role of synovial fibroblasts and other synovial cells in this process, and the molecular mechanisms involved in cartilage degradation.

In particular, saliva, which may closely reflect the underlying pathogenetic process in salivary glands, has been viewed as an attractive biofluid for proteomic research in pSS and a number of studies have so far outlined the potential differences between pSS and healthy controls [ 11- 17].

Similar(54)

Our ability to detect an association between IGF1 haplotypes with mammographic density in a primarily postmenopausal population may be because genetic variation may more closely reflect the most relevant lifetime exposures of IGF1 (for example tissue level) than single estimates of circulating levels.

Thus, cellular models established according to a protocol that mimics clinical treatment [ 2, 6, 39, 50, 51] (that is, long-term exposure to AIs) may more closely reflect the clinical situation and may be pertinent to investigation of acquired AI resistance.

Importantly like cell-based methods, the presence of tumour-specific or tumour-associated mRNA is thought to reflect the presence of the disseminating tumour cell or cells that may have the capacity to metastasise, and consequently may more closely reflect active disease status.

This suggests that elevated RBP4 and fetuin-A serum levels do not represent an independent mechanism linking adipose tissue dysfunction to impaired glucose metabolism, whereas chemerin may be closely reflect causation in obesity-related glucose intolerance.

Furthermore, saliva and urine cortisol may more closely reflect plasma free cortisol concentrations.

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