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It is speculated that PGE2 is elevated due to local inflammation, which may cause vasodilation in the cerebral arteries and induce AH [25].
Markedly increased circulating acetaldehyde levels after alcohol consumption may cause vasodilation, flushing of the face, nausea, and headache in approximately one third of people originating from East Asian countries who are homozygous or heterozygous for a defective form of aldehyde dehydrogenase-2 (ALDH-2), [8], [14], [15], [16].
In higher concentrations, H2O2 may cause vasodilation.
Taken together, leptin released by PAT may cause vasodilation or vasoconstriction, depending on the location of PAT.
Further pathophysiological mechanisms to explain the authors' findings are peripheral vasodilatation by NS and acidosis, which itself may cause vasodilation and impair endothelial integrity [ 3].
Another interpretation is that the increase in blood flow may cause vasodilation independently based upon oxygen level with dilatory agent (such as NO) and maintain adequate tissue oxygen level with the increased oxygen extraction [ 40].
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CO may also cause vasodilation through the activation of voltage-dependent potassium channels (Kv) [ 22].
The application of external heat may cause peripheral vasodilation and venous pooling, leading to relative hypovolemia and hypotension [ 35].
Acetylcholine interacts with endothelial muscarinic receptors to enhance nitric oxide (NO) release and thereby cause vasodilation.
Vasopressin also simulates oxytocin receptors to cause vasodilation [ 24, 25].
Sevoflurane could also cause vasodilation via inhibition of one or more calcium (Ca++) channels.
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