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Several neurotoxins and disease genes may cause variants of PD differing in age of onset, manifestations and prognosis, but a common pathway has remained elusive and a routine laboratory diagnosis cannot yet be provided to patients.
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Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation.
The number of false positive variants can be further reduced by cross-platform replication, but the different biases of the sequencing platforms may cause many true variants to be overlooked when cross-platform replicates are compared [ 72, 73].
Therefore, in this study, we removed one of the SNPs from a pair in which two SNPs were in complete LD although this may cause the loss of causative variants.
Earlier studies in sheep and cattle indicate that several variants of A. phagocytophilum exist and that these variants may cause different clinical and serological responses [ 15, 13].
But several experts said it was too early to know what mix of common and rare variants may cause the disease and whether that might affect the search for treatments.
CYP2D6 (cytochrome P450 2D6) is one of the most important enzymes involved in drug metabolism, and CYP2D6 gene variants may cause toxic effects of therapeutic drugs or treatment failure.
These variants may cause different clinical manifestations [ 4].
These studies suggest that MLH1 promoter variants may cause unbalanced constitutional expression of MLH1.
Certain IRF5 variants may cause prolonged inflammatory response and disrupt immune tolerance.
It was concluded that attenuated concentration of extra-cellular serotonin due to longer variants may cause higher susceptibility to CFS.
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