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Uncontrolled Wnt signaling may cause retinal diseases such as familial exudative vitroretinopathy, retinitis pigmentosa, and Norrie's disease, further underscoring the importance of the Wnt-signaling pathway in the retina.
However, the excess of illumination may cause retinal degeneration or accelerate genetic retinal diseases.
The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance and not only in extreme experimental conditions, as previously reported.
Some authors caution that readministration of intravitreal steroid for recurrent CME in npAIR and CAR is best done early when cystic changes are just starting to recur to avoid cycles of retinal cyst expansion and collapse which may cause retinal damage [2, 10].
In more than 80% of puppies and 50% of adult dogs that fail to mount an early successful immune response to CDV, the virus will invade the nervous system and may cause retinal damage (vision loss), tremors in the jaw muscles (called "chewing gum fit"), rhythmic twitches of muscles (called myoclonus), imbalance, and/or generalized seizures.
Our results suggest that TRPM1 is one of the retinal autoantigens in at least some patients with CAR or MAR and may cause retinal ON bipolar cell dysfunction.
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But in a spot of light that your eye can't resolve, it will actually hurt to look at it and may even cause retinal damage.
Besides FAME, in severe cases of MS with persistent inflammation, fingolimod may also cause retinal hemorrhage.
Aside from the above-mentioned presumed selection bias, the longer duration of 5000cs silicone oil retainment (mean, 23.9 months) compared to 1000cs silicone oil (mean, 10 months) with its attendant pressure effect on the retina may somehow cause retinal damage.
Additionally, although neuro-ophthalmic evaluation for associated optic neuritis is often part of multiple sclerosis disease management, the ophthalmologist must be careful to not neglect associated vasculitis or uveitis that may also cause retinal abnormalities including cystoid macular oedema and a subsequent reduction in visual acuity.
In advanced stages of the disease, preretinal membranes can form, which may contract and cause retinal detachment (Fig. 19) [1, 22].
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CEO of Professional Science Editing for Scientists @ prosciediting.com