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Our data suggest that high levels of CTCF may cause repression of Bax and inhibition of apoptosis.
Similarly, expression of ID1, an inhibitor that prevents DNA binding of basic helix-loop-helix transcription factors was up-regulated in presence of HIPPI which may cause repression of genes.
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Expression of PEG11AS may normally cause repression of the paternal PEG11 locus since very little PEG11 mRNA was detectable in the muscles of normal animals.
68 Therefore, in certain ONCs, high Crb may cause JNK‐dependent repression of Yki and "loser" status.
97 Altogether, these results suggest that DNA methylation rather than histone deacetylation may be the primary epigenetic mechanism to cause repression at this locus.
Compaction of DNA through binding to methylated H3K9 will cause repression, while compaction of RNA via interaction with hnRNP proteins may stabilize the messenger and support gene expression (Piacentini et al. 2009).
This may be due to increased recruitment of histone deacetylase complexes (HDACs) that are known to associate with activated p53 and cause repression of some target genes [ 31- 34].
In prion diseases, Giovanna Mallucci and colleagues have suggested that the toxic species may cause persistent translational repression of protein synthesis and concomitant synaptic failure and nerve cell loss.
It has been suggested that repression through elongation control may cause no change in Pol II binding on slp1 and Hsp70 (Adelman et al., 2006; Wang et al., 2007; Ardehali et al., 2009).
Terrorism goes on and it's feared it may cause a political swing to the right resulting in repression.
In one hypothesis, miRNA themselves may be the targets of other miRNA and hence the increase of one miRNA may cause a net increase in gene expression because of its repression of another miRNA targeting the same genes.
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