Sentence examples for may cause pathological from inspiring English sources
We postulate that this accumulation may cause pathological changes in the cells resembling some of those characteristic of age-related macular degeneration (AMD).
The results provide insight into the mechanisms by which amyloid aggregates may cause pathological effects in prion and amyloid diseases.
Increases in mucosal intestinal permeability may cause pathological leakage of bacterial products, inducing inflammation.
Leptospirosis may cause pathological changes in a great number of organs due to the endothelium damage it causes [ 9, 11].
The accumulation of aberrant mRNAs, which can be translated into deleterious truncated proteins, may cause pathological symptoms (Frischmeyer & Dietz, 1999; Hwang & Maquat, 2011; Palacios, 2013).
In addition, the extent of the physiological stress experienced in the ICU may cause pathological changes in the hypothalamic-pituitary-adrenal (HPA) axis (coordinates the stress response) which predisposes patients to PTSD [ 33].
However, the extent to which and the mechanisms by which 27-OHC may also cause pathological hallmarks related to AMD are ill-defined.
In other cases, mutation of UPS components may directly cause pathological accumulation of proteins, e.g., autosomal recessive Parkinsonism and spinocerebellar ataxias.
Thus, we concluded that uncontrolled long-term expression of hVEGF-A165 may cause significant pathological changes in target tissues and tight regulation of the transgene expression seems to be a prerequisite for all therapeutic applications aiming at long-term expression of hVEGF-A165.
UBC may cause repetitive pathological fracture and skeletal deformities during growth because of its proximity to the physis.
In definition, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits, which occurs when a new mutation in the gene may have an effect on some or all traits simultaneously or may cause different pathological effects in complex human diseases [ 14– 16].
