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Ultraviolet radiation joins adjacent thymines, creating thymine dimers, which, if not repaired, may cause mutations.
Misincorporation studies suggest that both HIV-1 RT and Pol γ may cause mutations at significantly high rates.
DNA damage threats to cells because it may cause mutations, alterations of chromosomal structures and loss of genetic information.
The recombination of PCR products in vivo may cause mutations of the shRNA region.
These react chemically with DNA which may cause mutations leading to neoplasia (Coughtrie, 1996).
190– 193 If not repaired, these adducts may cause mutations that can lead to endometrial cancer.
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Due to the break of slug, 'powder flooding' happens and may cause mutation in in-flight particle stream.
Oxidation at the C8 position of guanine (8-oxoguanine) may cause mutation due to its potential to mispair with adenine during DNA replication.
The main genotoxic damage generated by exposure to pollutants from biomass burning are oxidative types of damage (e.g.: 8-oxodG) and formation of DNA adducts, which if not repaired may cause mutation in DNA [ 13- 15].
There are related proteins that may likewise cause mutations; "this might just be the tip of the iceberg," Keinan says.
In conclusion, GBT had no genotoxic effects in various tests involving bacteria and mammals, suggesting that GBT may not cause mutations in bacterial systems or chromosome or DNA damage in vitro and in vivo.
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