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Given the very different mechanisms of the diverse instruments, the design or the selection of appropriate instruments may cause methodological difficulties.
First, relying on a BMI value recorded at a single time point, and early in pregnancy, may cause methodological issues provided that women can alter weight status throughout pregnancy.
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However, these studies were conducted on patients who came to the DS region for recreational as well as therapeutic purposes, which may cause a methodological bias in terms of improved HRQOL.
These missing data cause methodological challenges in analysing HRQoL data.
In this paper we discuss issues around external generalizability of single-center studies, and methodological issues that may cause bias.
Based on our experience as ophthalmologists, the major methodological issue that may cause a bias is, to our opinion, the way the assessment of the visual acuity was conducted.
This may cause incongruences between review authors with different levels of methodological training or content knowledge [ 55].
Important methodological features of the occupational cohort studies may cause their results to be biased toward the null.
This methodological option, chosen for economical and operative reasons, may cause a bias.
Methodological variability, particularly with respect to the antibodies and specimens used, may cause inconsistencies in the results obtained in the different studies.
But it may cause headaches.
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CEO of Professional Science Editing for Scientists @ prosciediting.com