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Laboratory studies have shown that, with the development of hyperuricemia, exposure of rats to intermittent hypobaric hypoxia could lead to renal microvascular and tubulointerstitial injury, suggesting that hypoxia itself may cause low-grade renal injury [ 30].
In addition to acute diseases causing severe morbidity and mortality, underlying chronic conditions that cause low-grade or subclinical infections may confound research results.
Chronic intake of a high-fat diet has been reported to cause low-grade inflammation.
The extent to which transfusion may cause further, low-grade risks is hard to assess, since subtle harms — as well as subtle gains — can easily go unrecognized in patients who are already critically ill.
It has therefore been proposed that P. acnes may cause chronic, low-grade infection in herniated discs.
Another possible cause of capsular contracture is the presence of bacteria growing as biofilm on the surface, which may cause persistent low-grade inflammation of the surrounding tissue, leading to formation of capsular fibrosis and subsequent contracture [ 69, 70].
Laser treatments to the eye may cause chronic low-grade inflammation, and the flare and cells in the anterior chamber might interfere with the measurement of intracameral fluorescein used in the determination of aqueous flow [ 23].
"He may have low-grade brains.
This low axial velocity may cause the low attack angle.
But it may cause 12th grade scores to lag.
It may cause a systemic low-grade inflammation and increased proinflammatory activity with elevated cytokine levels.
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CEO of Professional Science Editing for Scientists @ prosciediting.com