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It is well-known that admixture may cause linkage disequilibrium [43], [44] and since admixture may follow from rapid populations expansions and contractions this is yet another important consequence of postglacial range oscillations.
Factors such as close physical linkage among loci, inbreeding/selfing, genetic drift, or the Wahlund effect may cause linkage disequilibrium (LD) [ 28].
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It is also relevant to consider whether data or methodologic limitations may cause data linkages to fail to find associations observed in research studies with greater power or ability to control confounders.
The potential selection bias may cause the correct linkage rate to be overestimated, particularly for children aged 1 to 9 since they have more missing PHNs than those aged 10 or older in Vital Statistics data.
Such structural differences between chromosomes of the two species may cause problems in the linkage map that interfere with its use in ordering and orienting scaffolds.
Loss of cavin-3 linkage components may cause lipodystrophy through selective death in adipocytes (Martin et al., 2012); however, lipid mobilizing factors are elevated in the circulation of Cavin-3 KO animals (data not shown), suggesting that lipolysis is responsible for the loss of triglyceride stores.
The tetrahedrons are usually quite regular, and the silicon-oxygen bond distances are 1.61 ± 0.02 Å. Principal differences are related to the geometry of the tetrahedral linkages, which may cause small distortions within the silica tetrahedrons.
The first evidence indicating that inherited sarcomeric gene mutation may cause familial ASDII arose from a linkage study in 2006.
Second, it has been argued that ignoring gene conversion may cause problems in association studies (Wall, 2004a) and linkage analysis (Mancera et al., 2008).
These deficiencies may result in low resolution, large gaps, and incorrect marker order in the linkage maps, and in turn, may cause incorrect orientation or misplacement of scaffolds in the Glyma1.0 whole genome sequence assembly of soybean.
Attacks on the sugar moieties may cause strand breakages, whereas those on histone proteins may lead to cross-linkages that interfere with chromatin folding, DNA repair and transcription.
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