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7 12 It is well recognised that acid or basic drugs may cause lesion to the vascular endothelium.
Our observation that the stereotaxic injection of GSSG to the brain may cause lesion by a 12-lipoxygenase sensitive mechanism leads to question the significance of GSSG in numerous brain pathologies commonly associated with elevated levels of GSSG in the brain (58, 59).
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Inadequate oxygenation may cause lesions and brain atrophy during aging.
When swallowed, anthrax spores may cause lesions from the oral cavity to the cecum.
A variety of aetiological factors may cause lesions in skin, fins and eyes of fish under farming conditions.
Studies suggest iron overload may cause bone lesion.
These results indicate that under specific conditions GSSG may cause brain lesion in vivo via a 12-lipoxygenase dependent pathway.
On the other hand, the possible role of the cysteinyl leukotrienes has been proposed; in addition to constituting one of the principal inflammatory mediators of asthma, these molecules may cause endothelial lesion or dysfunction [ 38].
The well-established murine and cynomolgus monkey models have demonstrated that EV71 infection may cause neurological lesions in the CNS [ 11, 12]; recently, EV71 Virus infected rhesus monkeys through four route can result in lesion in the CNS [ 13].
Physical restrictions at the feed barrier may cause skin lesions, especially on the necks of cows.
Worm's toxins stimulate the production of gastrointestinal hormones like gastrin and cholecystokinin causing reduction of voluntary feed intake, as well as helminthes developing in the animal may cause local lesions and changes in plasma proteins (Fekete & Kellems, 2007).
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