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Pseudomonas aeruginosa is an opportunistic pathogen that may cause invasive disease.
However, in addition to Aspergillus spp., other fungi may cause invasive tracheobronchitis without affecting the galactomannan antigen levels [13].
In some circumstances, for example after organ transplantation, the fungus may cause invasive and life threatening systemic infections.
They may cause invasive infections predominantly in immunocompromised persons [ 2].
Unlike the three model species in the Aspergillus genus that have a long history of safe use for industrial enzyme production, A. fumigatus strains are opportunistic pathogens that may cause invasive aspergillosis in immunocompromised patients [ 29, 49], although strains in this species are also effective at biomass degradation.
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Because Aspergillus spp. are widely found in the environment, water, soil and in decomposing plants, spores can be easily inhaled and may then cause invasive pulmonary disease.
Streptococcus pneumoniae may cause severe invasive pneumococcal disease (IPD) which includes pneumonia, sepsis and meningitis [ 1].
In particular, it may cause early invasive lesions to be inadvertently treated by an ablative technique [ 2, 7].
In conclusion, the presented case shows that A. tubingensis may cause severe invasive infections in immunocompromised hosts.
These data fortify the hypothesis that deletion of genes essential for cell survival, adjacent to RB1, may cause less invasive tumors and, therefore, result in a higher frequency of unilateral disease [ 25, 26].
Although the prognosis is often satisfactory, clinicians, mycologists and epidemiologists should be aware of the possibility of infection by this uncommon fungal pathogen in diabetes patients, since it may cause severe invasive infections in immunocompromised hosts such as diabetes and AIDS patients.
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