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These changes may cause initiation of programmed cell death, or activation of several proto-oncogenes and/or inactivation of some tumour suppressor genes.
Free oxygen radicals lead to DNA damage (both directly and through lipid peroxidation) and thus may cause initiation and promotion of the carcinogenic process.
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Practically there is moisture present during the treatment, and therefore this may cause the initiation of oxidation and reduction reaction in cellulose-containing specimens.
Our present finding, that increased IL-6 secretion from monocytes predicts prognosis of HNSCC disease, further supports the notion that inflammatory responses may cause both initiation and progression of neoplastic growth [ 12].
It is known that the excessive dynamic response and stress level of the bridge under these rare but critical scenarios, even for a very short period, may cause critical damage initiation or accumulation on some local bridge members.
However, in this manipulation, the wax also covered some surface area of the third antennal segment so that it is possible that olfactory function was also disrupted, which may cause delayed courtship initiation.
This impairment of the early response may cause the delayed initiation of the cytokine response, resulting in the greater level of pathology (susceptibility to disease) in these birds.
This may cause an early crack initiation in the substrate adjacent to the coating.
Note that heterogeneities in frictional properties at further smaller length scales are not considered in our simulations, and hence potential cascade-up from them, which may cause complexity in the initiation of earthquakes as discussed later, is not included in the results.
Therefore, cyclin-dependent kinase 8 and five other transcripts down-regulated in the brain at diapause initiation may cause cell cycle arrest, inducing the insect to enter diapause.
Accumulation of α-synuclein might be causally linked to the progression of MSA, because α-synuclein aggregation in oligodendrocytes may cause demyelination, resulting in initiation of neurodegeneration [ 128].
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