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However, phenytoin is a negative inotrope and may cause hypotension; it may also interfere with coagulation function.
It may cause hypotension, but reduces intracranial pressure and brain metabolic requirements [ 130], and may also have immunomodulatory effects [ 131].
There is concern that anticoagulants and thrombolytics may cause bleeding and that vasodilators may cause hypotension – and therefore hasten death.
Furthermore, they may cause hypotension and cardiorespiratory depression, which may require the use of additional drugs to control pressure and breathing, as well as immunosuppression [ 138– 138].
They should not be administered to patients with low BP since they may cause hypotension and hypoperfusion of vital organs, leading to renal and/or myocardial damage which may further worsen patients' outcome.
Similar(55)
Even small doses may cause profound hypotension.
Sustained high pressure may cause transient hypotension, and may be less well tolerated than methods using higher pressure ventilation.
Remifentanil, 1.0 to 4.0 μg·kg-1 combined with propofol, provides acceptable intubating conditions [ 1, 2, 4], but these doses may cause arterial hypotension and severe bradycardia [ 7, 8].
Both drugs should be given by a rate-controlled intravenous infusion (infusion pump), and never by a bolus injection, which may cause fatal hypotension or cardiac arrhythmia.
On the other hand, atosiban is thought to be completely safe for the mother, whereas nifedipine may cause severe hypotension and fetal death [ 16].
Antihypertensive medication may cause nonphysiologic hypotension, rendering systemic pulse pressure and OPP fluctuation wider in subjects with autonomic dysfunction, and finally causing ischemia-reperfusion damage to the optic disc in glaucoma pathogenesis.
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