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A hypomethylated genome promotes proliferation and may cause genomic instability thereby contributing to tumorigenesis (Eden et al, 2003).
Since the integration of foreign sequences in the PVX genome, or the modification of the CP, may cause genomic rearrangements [ 18, 19], we have verified the integrity of the chimeric transcript.
More recent studies confirm that a weak THz field may cause genomic instability in human lymphocytes [6] after extended (6 hours) exposure.
As such, MASTL depletion may cause genomic instability.
We propose that mitosis with damaged DNA is a biologically significant event because it may cause genomic rearrangement in cells that survive genotoxic damage.
For example it was confirmed that a very weak CW THz field (0.031 mW/cm) may cause genomic instability in human lymphocytes [ 14] after extended (more than 6 hours) exposure.
Similar(51)
It is though that hypomethylation in the parental germline can influence genomic instability, and that this instability may subsequently cause genomic instability in the progeny [45].
Thus, mutation of any single gene may cause a genomic imbalance, with consequences sufficient to drive adaptive genetic changes.
Such inactivation of wild-type TP53, which may cause further genomic instability, has been frequently reported in advanced GCs [ 15, 17].
Lastly, as unrestricted transposition of TEs may cause deleterious genomic mutations, the majority of nuclear TEs would be suppressed by DNA methylation [ 15].
It is widely recognized that hybridization between genetically differentiated natural plant populations may cause structural genomic changes (e.g., via homoeologous or ectopic recombination) as well as perturbation of epigenetic state of the recipient genome (e.g., DNA methylation), and both may result in heritable phenotypic novelties [ 1- 7].
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