Irinotecan is activated in vivo after parenteral administration, metabolized by glucuronidation in the liver before excretion in bile, and then reactivated by bacterial glucuronidase in the bowel, where it may cause dose-limiting diarrhea.
AVP may cause dose-related adverse myocardial effects at infusion rates exceeding 0.4 U/min [ 134, 135], or even above 0.08 U/min in cardiogenic shock [ 136], which probably relate to direct myocardial effects, including coronary vasoconstriction [ 132, 137- 139].
The scattered radiation from external devices in radiotherapy may cause altered dose distribution among other complications.
Conventional irradiation of breast and chest wall tumours may cause high doses in underlying organs.
Source position displacement in organs with cavities such as the esophagus and the bronchi may cause the delivered dose to differ from the prescribed dose in the treatment plan and may bring unexpected influence to the treatment results.
Standard doses of acetaminophen are very safe; however, high doses may cause liver problems, and very high doses can be fatal.
Understanding the secondary inter-regional transport of the radioactive materials is also important in other regions because the re-suspended radioactive material by wind may cause significant internal doses (IAEA, 2006).
At each clinic visit, practitioners should query patients about the presence of AEs, particularly persistent AEs, low-grade AEs and AEs that may cause patients to skip doses or decrease their dose.
12 The steady-state 24-h pH HTRs in our studies (mean pH >4 HTR for the 40 mg dose on Day 7: Japan, ∼100%; UK, ∼93%) suggest that TAK-438 at the 40 mg dose level may cause more profound gastric acid suppression than that reported after PPIs.
As it is widely used in evaluation of dose distributions, we extend the use of gamma ratio to evaluate the difference between two respiration waveforms which may cause the change of dose distribution during radiotherapy.
Wilde was an epigrammatic genius, it's true, but too large a dose may cause stomach upset.
