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They may cause distal collapse of the lung or partial obstruction with 'ball valve effect' that causes obstructive and dramatic over-inflation of the distal lung.
Bronchial obstruction may cause distal infection which proves resistant to standard treatment, or breathlessness due to lung collapse.
Although fluid restriction may cause distal organ damage [ 14], hypervolemia has been associated with increased lung injury [ 16, 17].
Small aneurysms are usually asymptomatic, while large ones may cause distal embolism or occlusion of the perforating arteries.
Arsenic poisoning may cause distal symmetric peripheral neuropathy with burning and numbness in the hands and feet and a syndrome of rapidly developing ascending weakness similar to Guillain-Barré (Guillain-Barré syndrome is a disorder in which the body's immune system attacks part of the peripheral nervous system).
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Distal tubular disease may cause the characteristic distal renal tubular acidosis [ 18] (with hypokalaemia, nephrocalcinosis/kidney stones, osteomalacia and a variable metabolic acidosis) or nephrogenic diabetes insipidus [ 19] (NDI).
Exostoses of the distal forearm and their treatment may cause dysfunction of the stable distal radioulnar joint (DRUJ).
A major factor in this is compliance mismatch between the graft and the diseased vessel, which may cause intimal hyperplasia at the distal anastomosis.
Lack of sufficient soft tissue may cause mechanical irritation of the distal ulna [ 3].
Several conditions like syringomyelia, motor neuron disease, cervical spondylotic myelopathy, spinal cord tumor, and traumatic myelopathy may cause localized amyotrophy of the distal arm, and these should be excluded first by imaging modalities [ 33].
Posttraumatic deformities of the forearm bones (radius shaft, ulna shaft or distal radius) may cause impairment of the forearm function, i.e. limited range of motion (ROM), especially decreased pro- and supination and a painful or instable distal radioulnar joint [ 1, 2].
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Justyna Jupowicz-Kozak
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