Sentence examples for may cause conformational from inspiring English sources
Different from crystallography where the macromolecules are constrained within a crystalline lattice, single particle molecules in solution are more flexible in changing their ternary and quaternary structures which may cause conformational or compositional heterogeneity among the molecules.
Furthermore, alterations in silk processing may cause conformational changes in the protein structure potentially increasing or decreasing susceptibility to degradation.
Taken together, our results suggest that the formation of heterodimers between CXCR4 and CCR5 is a dynamic process and that ligand binding may cause conformational changes in pre-existing CXCR4 CCR5 dimers, destabilize CXCR4 CCR5STA heterodimers or promote CXCR4 CCR5Δ4 heterodimer formation.
Genetic polymorphisms of such cofactor(s) may cause conformational changes of the complex, which allows RUNX3-bound TCF4 to bind the Wnt target gene promoter.
Excess iron yields hydroxyl radicals, which may cause conformational changes in the nuclear and cytoplasm membranes and results in activation of oncogenes [ 1, 2].
The H64W mutation retains the aromatic properties of the side chain and is theoretically able to form a hydrogen bond with the heme, but the larger size may cause conformational challenges for such interaction.
These results suggest that lithium treatment may cause a conformational change of WFS1 protein, rendering the immunoprecipiation with anti-native-WFS1 antibody less efficient.
This in turn may cause the conformational change of PLD1 to expose the μ2 binding site of the PH domain which generates the output signal that triggers the translocation of AP2 to the plasma membrane and the endocytosis of EGFR.
Our data suggest that free radicals formed through photobleaching may cause a conformational change of the CaM which lowers their binding affinity with the peptide or its respective binding partner.
A153T is close to two highly conserved C-terminal cysteines forming a disulfide bond in the TSPN domain structure of TSP-1 [53] and may cause local conformational changes due to its buried position in the molecule.
These findings suggest that the S184 nonphosphorylatable Bax or dephosphorylation of Bax at S184 site may cause a conformational change by exposure of 6A7 epitope that leads to activation of the proapoptotic function of Bax, which is functionally opposite with the mobility shift derived from the phosphomimetic mutation at this site (i.e.S184E; Fig. 1 vs. Fig. 3).
