Interestingly, Rpn4 is recruited to a DSB and inhibition of Rpn4 degradation may cause a concomitant delay of the dissociation of Rpn4 and the proteasome from the DSB.
The same hepatotoxin may cause the concomitant occurrence of both death modes, depending on the circumstances including dose and preexisting vulnerability of hepatocytes.
However, alcohol consumption and HIV treatment can cause concomitant hepatotoxicity that may lead to inadequate adherence to the anti-TB treatment.
Although V1 receptor agonism may cause excessive vasoconstriction, concomitant stimulation of vasodilatory V2 receptors may potentially improve microcirculatory blood flow.
Increased bleeding tendencies may cause haematoma enlargement with concomitant mass effect on surrounding brain tissue.
Using peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for circulatory support, in patients with concomitant respiratory failure, may cause differential hypoxia [ 1].
In the death registry, multimorbidity may cause increased "competition" of mentions of concomitant causes of death in decedents aged ≥65 years, with diabetes not being mentioned in favor of other concomitant conditions.
While HIV, per se, and concomitant enteric infections may cause mucosal atrophy [ 28, 29], our findings suggest that antiretroviral drugs may also contribute to or aggravate any enteropathy secondary to infectious causes.
In such patients, hypertension and dyslipidemia may be involved in the development of intrarenal arteriosclerosis or glomerular ischemia to reduce GFR and albuminuria (34, 35), but concomitant PTC hypoxia may cause increased urinary megalin excretion.
Recognising this issue, some clinical trial protocols will document lists of medications that in their context are considered to carry these risks, for example, "any concomitant medications that may cause QTc prolongation or induce Torsades de Pointes (see the Appendix for the list of medications in Tables 1 and 2) or induce CYP3A4 function" and "concomitant use of CYP3A4 inhiibitors or inducers.
