Sentence examples for may cause broad from inspiring English sources

Variations in gene expression, mediated by epigenetic mechanisms, may cause broad phenotypic effects in animals.

Therefore, although the basal ganglia are the most susceptible sites to Mn neurotoxicity, it is also evident that Mn may cause broad spectrum neuropathological changes in both neurons and glia in other brain regions, which may account for some of the nonmotor symptoms associated with this disorder [ 1].

For instance, Yao and Rzhetsky [ 25] utilized the protein betweenness centrality in a PPIN to predict drug-target interactions (DTIs) with the assumption that good targets should be of low "betweenness centrality" since the interruption of those highly connected nodes in the PPIN may cause broad and often unintended consequences.

It is known that SLE may cause a broad range of neurological and psychiatric symptoms that can precede the onset of lupus or occur at any time during the course of the disease.

Since cilia are present throughout the whole body, mutations in ciliary genes may cause a broad phenotypic spectrum.

ARVC/D is characterized by structural derangements that may cause a broad range of signs and symptoms.

Therefore, the electrophoretic mobilities of BSA species with different numbers of labels may cause the broad signals shown in Fig.  5a.

Interestingly, in a cohort of 40 patients displaying a vascular EDS-like phenotype but normal collagen III biochemistry, 30%% carried TGFBR1/2 mutations [ 32], suggesting on the one hand that vascular EDS closely resembles LDS but on the other hand that TGFBR mutations may cause a broad spectrum of diseases associated with aortic aneurysms.

We do not expect that F351A and KCNE1 would cause exactly the same changes because F351A causes only a focal change in the VSD-pore interactions while KCNE1 may cause a more broad change due to its larger interaction surface.

However, organic dyes, luminescent proteins or lanthanide chelates as bio-labeling agents may cause problems such as broad spectrum profiles, low photo-bleaching thresholds, and poor photochemical stability.

The interaction between placental malaria and MTCT appears to be variable and complex: placental malaria that is controlled at low density may cause an increase in broad-based immune responses that protect against MTCT; uncontrolled, high-density malaria may simultaneously disrupt placental architecture and generate substantial antigen stimulus to HIV replication and increase risk for MTCT.