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The bystander signals involved in this process may cause altered gene expression, damage in the DNA and chromosomes, cell proliferation alterations, cell death or changes in the translation process in non-irradiated cells (Najafi et al. 2014).
The scattered radiation from external devices in radiotherapy may cause altered dose distribution among other complications.
Similar to the mechanism of ethanol's effect, the increase of gas dissolved in nerve cell membranes may cause altered ion permeability properties of the neural cells' lipid bilayers.
It has been established that various maternal factors may cause altered fetal growth and development [29], but the impact of maternal genetics and epigenetics in the development of birth defects is not well understood.
The endothelial dysfunction may cause altered blood flow responses [ 29].
Psychosocial factors, such as e.g. daily stress may cause altered gut physiology leading to ileum contractions and consequently gastrointestinal symptoms.
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The parasite causes toxoplasmosis, which has been shown to cause altered dopamine levels, which in turn may cause schizophrenia, OCD, ADHD, and mood disorders.
Together, the data predict that the PAPA-associated mutations may cause an altered cellular distribution of PSTPIP1 in a manner that has the potential to directly impact inflammatory signaling.
This polymorphic variant may cause some altered catalytic specificity with various substrates.
Furthermore, changes in one's activities may cause an altered self-identity, as the activities that once contributed to defining self are no longer applicable.
Yet, the common loss of expression of HLA-A and -B in 3 of 4 sporadic MSI-H tumors, which is not due to B2M frame shift mutations, would suggest that another general mechanism may cause this altered phenotype.
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