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In contrast, in relation to neuronal degeneration, oxidative stress may cause activation of stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK).
SPG stimulation may cause activation of sensory fibers from the second division of the trigeminal nerve (V2).
This may cause activation of alternative proangiogenic factors and lack of efficiency of VEGF blockade.
Such a change, in accordance with the principles of epigenetics, may cause activation of genes.
It will also be revealing to determine whether Erk signaling may cause activation of pTEFb (Fujita et al., 2008; Lee et al., 2010).
Binding of Ephrin to the EphR may cause activation and deactivation of the Eph and Ephrin downstream signaling cascades resulting in altered cell-to-cell interactions and cell migration.
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To conclude, it seems likely that odours, visual or acoustic stimuli may weaken conditioning effects and may cause activations in different brain regions than electrical stimuli.
Abnormal functional levels of BRCA1 in prostate cancer may also cause activation or inhibition of STAT3 (signal transducer and activator of transcription 3) [ 37], which is predicted by our computational model.
Therefore, in addition to acting as an antigen source, the injected DCs may also cause activation of endogenous recipient DCs without further stimulation.
Further, pIRS-1 may also cause activation of alternate proliferative pathways implicated in carcinogenesis, including the extracellular signal-regulated kinase mitogen-activated protein kinase pathway.
Sidani et al. suggested that complete ablation of the CFTR gene may potentially cause activation of compensatory mechanisms such as up-regulation of non-CFTR regulated K+ channels (Sidani et al., 2007).
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