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As insulin induces global protein synthesis, it may cause accumulation of unfolded proteins in the ER, thus triggering UPR.
Moreover, the wide variability of the chemical composition of manure may cause accumulation of one or more nutrients in the soil (Galvão et al. 2008), as the P, for example.
Heat shock may cause accumulation of misfolded or aggregated proteins in the ER that need to be removed through the ERAD pathway.
During the estrous cycle, ovarian surface epithelium undergo cycles of trauma and proliferation with each ovulation accompanied by hormonal surges and inflammation, which may cause accumulation of genetic damage and ultimately lead to the development of ovarian cancer [1].
Additional steps of sperm transfer may cause accumulation of sperm damage and ultimately decrease sperm quality more severely than simple and direct ejaculation from the male reserves to the female storage organs.
As the half-life of Cd in human body is about 15 20 years [1], chronic exposure to a Cd-contaminated environment or food chain may cause accumulation of Cd in various human organs, such as kidney [2], liver [2], [3], lung [4], [5], testis, bone and brain [6], [7], thereby leading to their damage.
Similar(42)
A surfactant that degrades only partially may not only have adverse effect on petroleum hydrocarbon degradation due to reduction in surface activity, but may also cause accumulation of recalcitrant intermediates in the environment.
The ΔtolC mutation may also cause accumulation of toxic metabolites inside the cell, which activates the BaeSR and CpxR stress response pathways [ 37, 38].
The accumulation of BubR1 and Mad2 in the absence of functional p53 may cause the accumulation of APC/C substrates (cyclin A/B, securin, aurora-A, and Plk1) and may evoke some mitotic errors that induce chromosomal aberrations such as polyploidy 7– 39. p53 could play a critical role in the suppression of OS-initiated mitotic errors through downregulation of SAC factors.
Clearly, the deficiencies of each of these chaperones may cause protein accumulation in the cytosol and the decline in mitochondrial activity.
Most of the dug well showed Na% greater than 60%% which may cause salt accumulation in the soil during repeated irrigation.
More suggestions(15)
may cause liver
may prevent accumulation
may include accumulation
may cause memory
may involve accumulation
may enhance accumulation
may represent accumulation
may favor accumulation
may facilitate accumulation
may cause distress
may cause suffocation
may cause scalp
may require accumulation
may reflect accumulation
may cause hyperactivity
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