Such transient subpopulations of cancer cells with stem cell character may not only have an increased innate ability to resist chemo and radio therapies [ 14– 16], but may carry a specific profile of developmental signals, which could make them amenable to therapeutic approaches through specific pathway antagonists.
The competition instructions may carry a specific indication, but in the absence of such an indication, only one entry/ vote per entrant (or household, computer or other unit as appropriate) will be permitted.
Together these observations add to the growing realisation that common plasma proteins may carry disease specific peptides and therefore should not be ignored in biomarker research.
Currently, many studies show that highly repetitive DNA may carry out specific cellular functions (Podgornaya et al. 2013) and their rapid evolution may be involved in the speciation process.
Intuitively, if for example, the descriptors are binary indicators of specific structural features in each small molecule and proteins, then the product of two such features indicates that both the small molecule and the target carry specific features, which may be strongly correlated with the fact that they interact.
However, a growing body of evidence suggests that the UPS plays a critical role in the parasite-specific life style and it is therefore intriguing to unveil the proteins and pathways that are associated with or regulated by the UPS [ 64, 65], as they may carry out functions specific to pathogenesis or virulence.
Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types.
Such sex-specific effects may carry indirect effects on males since competition for high quality females could also affect selection strength on males.
Even if a central service for wheat becomes available, individual researchers may need to TILL genotypes carrying specific alleles (such as for disease resistance) that may be absent in available TILLING populations.
