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It is possible that such genotypes may carry mutations that increase resilience to iron limitation.
Yeast mutants that are sensitive to growth under respiratory-prone conditions (defined medium) and to H2O2 on low-respiratory medium (complex medium) may carry mutations in genes that participate in the generation of respiration-linked basal oxidative stress.
Finally, these patients may carry mutations in as yet unknown genes.
Among the others, a fraction may carry mutations in rarer BC genes, such as TP53, STK11, CDH1 and PTEN.
Such activation is clinically undesirable because cells may emerge as resistant, once they are relieved of the drug pressure, or may carry mutations that drive their aggressiveness.
Finally, also mitochondrial DNA (mtDNA) may carry mutations which through impairment of OXPHOS, increased ROS production and increased proliferation contribute to tumor progression [ 63].
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Other genes besides 19p13.3 may also carry mutations.
Patients belonging to the latter group may either carry mutations in genes different from those commonly found in PNDM/MDI or have developed an early-onset form of autoimmune diabetes.
Among our 23,000 genes, you may carry 500 mutations while I carry 1,000.
The presentation of the 11 cases may form part of the clinical spectrum of the MAS and, therefore they may carry activating mutations in the GNAS1 gene.
It is possible that an individual may carry multiple mutations within a single generation.
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