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Nonhuman primate (NHP) studies may bridge important rodent findings to the clinical realm since NHP-depression shares significant homology with human depression and kinetics of primate neurogenesis differ from those in rodents.
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Recent studies both in vivo and in vitro show that Wnt signaling may bridge the gap between the two pathological products, where GSK-3 β is an important mediator in the production of AD pathological products [ 19– 22].
CWP may bridge the gap between the two.
The broader distribution that we observe for Kar1 along the extended half-bridge may be important for its association with pore components of the SPB (discussed below).
These asymmetries may be important for bridge expansion, contraction, and bending, which have previously been proposed to facilitate formation and NE insertion of the new SPB (Adams and Kilmartin, 1999, 2000).
Nevertheless, bond occurrence was characterized by relatively prolonged time intervals (Table 2), indicating that salt bridges may play an important role in stabilizing the connexins fold.
An important and challenging question arising from our findings is how the identified disconnect between relevance and excellence may be bridged to ensure that future MHPSS research is both practically relevant and scientifically excellent.
This kind of bridging function may be particularly important in organogenesis.
It was suggested earlier that both salt-bridge and cation-π interactions may play important roles in thermostability [ 42].
In the dynamically equilibrated model, Asp97 forms a salt bridge with Arg28 of CDR1 that may be important for maintaining a correctly oriented loop structure (Fig. 5C).
Unreduced gametes may be important in polyploid evolution via a triploid bridge [ 1].
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