Sentence examples for may both directly from inspiring English sources

We therefore suppose that ANP may both directly and indirectly disrupt the inter-organ crosstalk following renal IRI.

According to this model, socio-economic factors may both directly or indirectly influence all the remaining groups of risk factors (with the exception of sex and age).

As presented earlier, evidence suggests that IL-1β may both directly [ 83- 85] and indirectly promote lipolysis.

Increases in IL-1 may both directly stimulate the expression of MMP-10 and cause indirect increases in MMP-10 expression through stimulation of NGF expression.

Preclinical studies in healthy volunteers have shown that acute hyperglycaemia and insulin resistance may both directly influence inflammation and coagulation [ 50, 51], but these changes may not be detectable on the background of the much larger abnormalities attributable to sepsis.

In smooth muscle cells, palladin may promote contractility both directly via enhanced actin bundling and indirectly, by regulating the expression of cytoskeleton-associated proteins including myosin, actin, calponin and h-caldesmon [9].

Present results may be explained by the pathophysiological mechanisms related to pleiotropic action of vitamin D. In particular, vitamin D may affect both directly, via activation of vitamin D receptors, and indirectly, via regulation of calcium availability, glucose and insulin homeostasis by modulating β-cell function and immune response, and improving peripheral insulin sensitivity [ 1, 2, 15].

Helminths may therefore both directly improve insulin sensitivity via a caloric restriction state and indirectly via Th2 activation.

These cells may act both directly, killing target cells, and indirectly, as either inducer or regulatory cells influencing innate and adaptive immunity (a "two-edged weapon") [ 3].

Interesting data suggesting a dialogue between vertebrate insulin and mosquito receptors (Pakpour et al., 2012) raise the fascinating possibility that the antiparasitic activity of mosquito may be both directly and indirectly mediated.

It is now hypothesized that either the proteins in the hard corona adsorb directly to NPs surface while proteins in the soft corona bind to the hard corona via weak protein protein interaction or the hard and soft corona proteins may both bind directly to the NPs surface with distinct binding energies [25].