These findings suggest that endogenous β-catenin is required for maintaining mTEC differentiation and may block cTEC differentiation.
Down-regulation of C/EBPα in keratinocytes can be permissive for cell proliferation and may block squamous differentiation.
Since it is known that IFNγ can suppress IL-23 [ 74], the programming of the peritoneal cavity to produce IFNγ may block the differentiation of Th17 cells.
HOXB7, which has higher expression in the control cells, may have a role in neoplasia, as it was shown to block differentiation of myelocytic cells [ 58].
This may be due to a high dose of IL-7, which has been reported to block differentiation of adult progenitors into T cells [24], [25].
Dox treatment does not entirely block differentiation.
However, it is not sufficient to completely block differentiation.
Interestingly, Dp53 can only block differentiation if it is expressed before the onset of differentiation.
Downregulation of NANOG will result in differentiation, while expression will block differentiation of ES cells.
Dpn and E spl)C may act simultaneously to modulate the expression of a set of genes that is required to control proliferation, which is likely to block differentiation and allow cell cycle progression.
