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Together, the comparison of DRCs for purine-like leads suggests that 5– 8 may bind the ATP-binding pocket in a different orientation than adenine and that the enzymes are highly discerning about what moieties can be added at this position as a large number of related molecules did not inhibit multiple HKs (Supporting Information Table 1, compounds S4, S27 38).
All members of this class share a conserved DNA binding domain and thus may bind the same stretch of DNA while interacting with other proteins to lead to differential patterns of expression both temporally and spatially [44].
We speculate that Hdf1p may bind the natural ends of the chromosome, in addition to binding to the ends of broken DNA molecules.
Third, the proximity of the MYB and AuxRE binding sites in one of them (IAA19) suggested that ARF7/MYB77 heterodimers may bind the composite elements in the promoter of certain auxin-responsive genes.
The ankyrin groove of ankyrin-repeat domains is a common binding site for protein protein interactions, suggesting that this region of ASB9 may bind the substrate and orient it in a suitable way to allow polyubiquitination.
However, the binding polypeptide is displayed in several copies at the phage surface and may bind the ligand at several different sites, and subsequently, the interaction may not easily be inhibited by free ligand even if added in excess.
Similar(22)
Similarly, EHD2 may bind to the transferrin receptor (which possesses a YXXφ motif) or to as of yet unknown proteins which mediate FM-4-64 internalization.
This low relative signal may bound the sensitivity of the current state of this technology.
The RdRp may bind to the CRE in the 3′ NCR of the HEV genome, which could play an important role in HEV replication.
In practice, not all the aptamers may bind to the MBs and therefore the actual binding capacity of two thrombin binding aptamers toward thrombin may be slightly greater.
Unlike the sulfonamides the anions may bind to the metal ion in three different coordination geometries: trigonal-bipyramidal geometry, tetrahedral geometry, or in a distorted tetrahedral geometry.
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