Furthermore, when an employee is a team member or, worse, a team leader, a whole group may become dysfunctional through the unexpected absence of that one person.
Through the combination of these extinction events, we see that many natural systems may become increasingly unstable and subject to unexpected consequences with changes to the matrix environment.
The responses may not persist over the long term, and unexpected side effects may become evident as a larger number of patients receive these new treatments.
Hepatotoxic effects may become only apparent in human beings, and unexpected human liver toxicity is one of the main causes for failure of promising drug candidates in development.
Incidental findings are test outcomes that are unintended or unexpected, for example: SNP-data which are not yet of predictive ability, but may become so in the future as new SNP-disease associations are being discovered.
As such, unexpected biological property changes e.g. reduced viability or increased shear sensitivity of newly introduced strains may become apparent during the primary recovery stage investigations.
Clearly, changes to eligibility criteria may become necessary, for instance because of problems during the study course such as slow recruitment of trial participants or unexpected side effects in a particular group of participants.
However, for the same reason they may become a great obstacle to the ability of paying attention to the first weak signals that precede the occurring of unexpected events.
Here the distress and anxiety of sudden, unexpected illness in a relative or close friend may lead to a change in attitude; positive views may become negative when the surrogate is under stress [ 9].
Breathing may become difficult.
