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Under some conditions the combination may become uncoupled.
Moreover, regional CBF may become uncoupled from metabolism during stimulation[12], [13].
For example, the initiating events and the downstream hemostatic response may become uncoupled under certain circumstances in vivo.
Although a parallel relationship between tumour perfusion and metabolism might be anticipated, several studies have shown that perfusion and metabolism may become uncoupled.
However, under conditions of increased ROS, endothelial NOS (eNOS) may become uncoupled (45) and produce O2−, which can react with inducible NOS (iNOS -produced NO to form hiNOS -producedreactive NOtoic species.
However, it has become clear from studies with the purified enzyme that eNOS may become uncoupled in the absence of the NOS substrate L-arginine or the cofactor tetrahydrobiopterin.
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This dualism may have become uncoupled from religious belief, but it remains fundamental to the western philosophic tradition; so much so, that when we fixate on those vulnerable heads, we cannot help suspecting the Islamic State's evil Beatles of intuiting our thoughts and bespoke tailoring their grotesque mise-en-scène for us, and us alone.
An alternative interpretation is that the mechanisms regulating homeostasis and regeneration may have become uncoupled in activin-1 RNAi). activin-1 RNAi
In addition, the nuclear density appeared to be decreased in some RnrL A4B5, UAS-yki clones and cell size increased, suggesting that cell growth and cell-cycle progression may have become uncoupled.
Similarly, AVP non-responders in the study population of Sacha et al. [7] may well represent patients with either a hypodynamic circulation or late septic shock when the microcirculation had become uncoupled from the macrocirculation, meaning that increases in systemic blood flow do not translate into improved microcirculatory blood flow and tissue perfusion any longer.
Late in life, Comfort regretted that he was no longer regarded as a poet; that his name had become uncoupled from those of his less-forgotten contemporaries.
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