Sentence examples for may become refractory from inspiring English sources

In support of this hypothesis, emerging experimental evidence suggests that tumors may become refractory or even evade the inhibition of a single pro-angiogenic pathway via compensatory upregulation of alternative angiogenic factors.

Nevertheless, patients may become refractory to syndrome control, and need incremental dosage increases of SSA.

Regardless of the GAD diagnosis, many patients consulting with anxiety symptoms remain symptomatic despite using treatments with an anxiolytic effect and, after a few months, may become refractory to therapy.

Advances in the neuromodulation field have also benefited people with the chronic subtype of CH who may have become refractory to the limited arsenal of pharmacological treatments available.

28 29 However, the Expert Committee felt that, while being an important step and a major alternative goal, reaching LDA could only pertain to patients with long-standing RA whose disease may have become refractory to therapeutic intervention.

Desensitization of the HPA axis might involve the loss of CRH receptors in the anterior pituitary, which in turn may induce the corticotrophs to become refractory to CRH hypersecretion during restraint stress.

As such, the effects of BVZ may be transient such that tumors shortly thereafter become refractory to therapy, highlighted by increased severity of aggressive and infiltrative phenotypes.

119 Thus, for men who do not respond to, are intolerant of, or become refractory to current drug treatments, drugs that inhibit fibrosis may prove useful.

Overall these results indicate that treatment with SeocalcitolTMmay prove effective when patients become refractory to anti-oestrogen therapy, and that Bcl-2 may be used as a predictive marker.

Around 25 50% of patients with trigeminal neuralgia (TN) become refractory to drug therapy, and surgical procedures are not always feasible in these patients, and they may occasionally result in severe complications [8].

Therefore, a possibility to become refractory to treatment is more with NDPH than any other CDH.