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However, elevated HPA axis activity in response to environmental disturbance may become pathological, resulting in reduced fecundity and survival, a key conservation issue for species of concern [ 41].
Widespread MC activation may become pathological when viral titers are high on a systemic level and, as in additional pathological contexts, MC responses in the context of systemic infection could reach a point where they become detrimental to the host.
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Reductions in GCase activity may represent a progressive reduction in lysosomal function with normal aging, which may eventually become pathological to the cell.
The high expression of HSP47 can be detected in the circulatory system of scleroderma patients, indicating that HSP47 may become a pathological marker to assess the progression of scleroderma, and also explain the systemic fibrosis of scleroderma.
A painting that can never be finished may be the sign of a patience so extreme it has become pathological.
Under extreme circumstances, the effects of histamine become pathological, leading to exaggerated responses with distressing results, as may occur in some allergic conditions.
When does healthy fear run amok and become pathological?
Politics has become pathological.
When does denial become pathological?
The prisoners had become pathological and the guards had become sadistic.
They become pathological or piles when swollen or inflamed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com