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Although part of the tumour may become malignant, it usually does not spread, nor does it recur once it is removed.
Another rare subset of chondroblastomas may become malignant.
Although most of the melanomas have a long initially benign growth period, up to 66% of these tumours may become malignant with metastases formation in other organs [ 15].
Nevertheless, adenomatous change may occur in polyps and they may become malignant, and an increased risk of jejunal and other small bowel tumours is recognised (Gruber et al, 1998).
If additional mutations involve genes responsible for cell adhesion and movement, aberrant epithelial cells may become malignant (colon cancer) and invade surrounding and remote tissues, creating secondary tumors called metastases.
Both rodent and primate studies indicate that gravid females are also at elevated risk for carcinogenesis, in part because of the presence in the placenta of trophoblastic tissue which may become malignant.
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Pre-existing cancerous lesions may become more malignant by the accumulation of new oncogenic mutations (such as Snail) that can induce cell dedifferentiation.
If most CIN3s eventually regress cytologically, an increasing proportion will be missed as the screening interval increases and many may not reappear until they become malignant.
And in some cases, we may be finding cell changes that will never become malignant.
Fourth, we do not believe M. hyorhinis itself causes malignant transformation, but when present it may further stress cells that have the propensity to become malignant as was evident in our preclinical study [ 15].
Although most adenomas will never turn into cancer, some will eventually become malignant, transforming to stage I CRC and some may even progress into stage IV.
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