Only later repressive histone modifications become introduced.
However, as the rotor will sooner or later become saturated with toluene, it may become necessary to introduce a regeneration procedure in order to periodically remove toluene from the rotor.
During product lifecycle it may become necessary to introduce minor changes (e.g., to continuously improve it) or major changes in the validated process (e.g., moving it to a new production site, replacing process version or even disruptively changing processing type).
Depending on the method of reconstructing the RVOT, the pathway may become obstructed, which introduces a pressure load on the RV, and/or there may be progressively severe pulmonary regurgitation (PR), which results in an RV volume load.
Given the large sample sizes needed to detect the association of genetic variants with modest effects in disease [25], the statistical bias introduced may become more pronounced in real settings [39].
First, low pathogenic avian influenza virus (LPAIV) strains of the H5 and H7 subtypes, which are known to circulate in wild birds, may become highly pathogenic (HPAI) if introduced into poultry and cause high morbidity and mortality with severe economic consequences [1].
As such, unexpected biological property changes e.g. reduced viability or increased shear sensitivity of newly introduced strains may become apparent during the primary recovery stage investigations.
Analogously, after safety limits of dosage were introduced, authors may become less likely to report cases of PRIS caused by propofol doses which had exceeded these limits.
On the contrary, the introduced exotic species may become invasive and result in negative impacts to native forests (Thijs et al. 2014; Macfarlane et al. 2015).
A role of exotic or native species in reclamation needs careful consideration as newly introduced exotic species may become pests in other situations.
