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Within a clinical perspective, genetic profiling for, for example, type 2 diabetes may become clinically valid in the future, and thus capable of disclosing informative and reliable risks, but it may not necessarily become clinically useful.
We might not appreciate late cardiovascular sequelae that may become clinically important later in life.
As we learned from animal models, biological changes of ALS started early in life however the manifestation of the disease may become clinically apparent much later.
Santorinicele has been suggested as a possible cause of relative stenosis of the accessory papilla that may become clinically relevant when it occurs in association with PD or IPD, resulting in recurrent episodes of acute pancreatitis.
Moreover, with new therapies, especially biological therapy (antibodies to tumor necrosis factor alpha drugs, anti-TNF), the presence of abscesses should be ruled out before starting the treatment, because undetected abscesses may become clinically apparent (with risk of sepsis) only after the closure of the drainage from a fistulous tract.
Thus, HPV systems with improved sensitivity and specificity may become clinically useful.
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The corollary is of course that intensive exposure to skeletal surveys may result in the treatment of lesions which may never become clinically significant.
They may not be subjectively aware of the toxic exposure, which may lead them into a false sense of security, especially as silent genotoxic effects may only become clinically manifest years after exposure [ 40- 43].
Although visual impairment may not become clinically apparent due to the peripheral distribution of these lenticular lesions relative to the iris, it is certainly the case that Aβ molecular pathology in the lens may be amongst the earliest expressed age-dependent phenotypes in Down syndrome.
Renal complications may not become clinically overt until the second decade of life.
The impact of the structure-modifying effect of CS on disease symptoms may also become clinically significant only after an extended period of treatment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com